TM Widely-Targeted Metabolomics
TM Widely-Targeted Metabolomics
TM Widely-targeted metabolomics is the 'Untargeted metabolomics + Targeted Metabolomics' process that achieves the perfect combination of high resolution, wide-coverage, high sensitivity, and precise quantification. It is a great starting point to examine the global metabolite profile. Metware's curated database of 280,000 metabolites, which includes 3000 metabolites not found in public databases, allows more annotations from high-resolution mass spec data.
Technology Introduction
"TM" Widely-Targeted Metabolomics combines Untargeted metabolomics and Targeted metabolomics to achieve the perfect combination of high-resolution, wide-coverage, high-sensitivity, and precise quantification. Metware's patented Widely-Targeted Metabolomics technology stands out from many others with features such as:
- Using high-resolution mass spectrometers to allow the unbiased collection of MS/MS spectrum data;
- Highly curated metabolomics database with over 3000+ in-house metabolite database providing more metabolite annotation;
- Using MRM analysis from QQQ to accurately quantify metabolites in each sample.
TM Widely-Targeted Matabolomics Service Technical Features
Large Curated Database
Collected ultra-high resolution data of over 280,000 metabolites. Each sample can typically identify over 1400 metabolites.
Rigorous Quality Control
A mature quality control system monitoring all aspects of experimentation from sample preparetion to data analysis.
Experienced
Stable and tested sample preparation protocol stemming from processing over a million samples a year.
Accurate Identification
Combining AB SCIEX QTOF 6600+ ultra-high resolution mass spectrum with our large curated database to achieve accurate metabolite identification.
Accurate Quantification
Using MRM mode from AB SCIEX Triple Quad 6500+ to achieve accurate relative quantification of metabolites.
Applications of TM Widely-Targeted Matabolomics Service
- Clinical marker discovery and development
- Understanding mechanisms behind disease progression
- Studying drug efficacy and toxicity
- Environmental toxicology research
TM widely-tagregetd Metabolomics Service Case Study
SERVICES
Bile Acid
Oxylipin Targeted Metabolomics
Neurotransmitter Targeted Metabolomics
Steroid Hormone Targeted Metabolomics
Energy Metabolism
Tryptophan Targeted Metabolomics
Amino Acid Targeted Metabolomics
Short-Chain Fatty Acids
Plant Hormone Assay
Carotenoid Targeted Metabolomics
Anthocyanin Assay
Gibberellin Assay
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List of Metabolites
The in-house standard database contains 3000 metabolites as shown below:
| Category | Quantity | Representative substance |
|---|---|---|
| Amino acids and their metabolites | 600+ | Glycine, L-threonine, L-arginine, N-acetyl-L-alanine |
| Organic acids and their derivatives | 400+ | 3-hydroxybutyric acid, adipic acid, hippuric acid, kynurenine |
| Nucleotides and their metabolites | 200+ | Adenine, 5'-Adenine Nucleotide, Guanine, 2'-Deoxycytidine |
| Carbohydrates and their metabolites | 100+ | D-glucose, glucosamine, D-fructose 6-phosphate |
| Lipid | 500+ | O-acetylcarnitine, γ-linolenic acid, lysophosphatidylcholine 22:4 |
| Benzene and its derivatives | 500+ | Benzoic acid, 3,4-dimethoxyphenylacetic acid, 4-hydroxybenzoic acid |
| Coenzymes and vitamins | 60+ | Folic acid, pantothenic acid, vitamin D3 |
| Alcohols, amines | 150+ | Dopamine, histamine, DL-1-amino-2-propanol |
| Aldehydes, ketones, esters | 120+ | Furfural, ethyl butyrate, α-pentyl cinnamaldehyde |
| Heterocyclic compound | 200+ | Pyridoxal, biopterin, indole-3-acetic acid |
| bile acid | 40+ | Glycocholic acid, deoxycholic acid, taurolithocholic acid |
| Hormones and hormone-related substances | 100+ | Juvenile hormone 3, epinephrine, 3,3'-diiodo-L-thyroxine |
| Tryptamine, choline, pigment | 15+ | Serotonin, bilirubin (E-E), urobilin |
| other | 50+ | Astaxanthin |
| total | 3000+ | |
Analysis Content Display of TM Widely-Targeted Metabolomics Service
Our complete service includes various data analyses to jump start your research. Below are a few components that you may find in our data analysis report.
SERVICES
Bile Acid
Oxylipin Targeted Metabolomics
Neurotransmitter Targeted Metabolomics
Steroid Hormone Targeted Metabolomics
Energy Metabolism
Tryptophan Targeted Metabolomics
Amino Acid Targeted Metabolomics
Short-Chain Fatty Acids
Plant Hormone Assay
Carotenoid Targeted Metabolomics
Anthocyanin Assay
Gibberellin Assay
WHAT'S NEXT IN OMICS: THE METABOLOME
Please submit a detailed description of your project. We will provide you with a customized project plan metabolomics services to meet your research requests. You can also send emails directly to support-global@metwarebio.com for inquiries.
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